| Peter Horton | Harry Landers (segment "Hospital") |
| Griffin Dunne | Doctor (segment "Hospital") |
| Brian Ann Zoccola | Nurse (segment "Hospital") |
| Joe Pantoliano | Sy Swerdlow (segment "Hairlooming") |
| Stanley Brock | Customer (segment "Hairlooming") |
| Steve Forrest | Capt. Steve Nelson (segment "Amazon Women on the Moon") |
| Robert Colbert | Blackie (segment "Amazon Women on the Moon") |
| Joey Travolta | Butch (segment "Amazon Women on the Moon") |
| Forrest J. Ackerman | U.S. President (segment "Amazon Women on the Moon") |
| Sybil Danning | Queen Lara (segment "Amazon Women on the Moon") |
| Lana Clarkson | Alpha Beta (segment "Amazon Women on the Moon") |
| David Alan Grier | Don 'No Soul' Simmons (segment "Blacks Without Soul,' 'Don 'No Soul' Simmons") |
| B.B. King | Himself (segment "Blacks Without Soul") |
| William Bryant | Male Republican (segment "Blacks Without Soul") |
| Roxie Roker | Female Republican (segment "Blacks Without Soul") |
| Le Tari | Pimp (segment "Blacks Without Soul") |
| Christopher Broughton | Fan Club President |
| Rosanna Arquette | Karen (segment "Two I.D.'s") |
| Steve Guttenberg | Jerry (segment "Two I.D.'s") |
| Henry Silva | Himself (segment "Bullshit or Not") |
| Sarah Lilly | Prostitute (segment "Bullshit or Not") |
| Archie Hahn | Harvey Pitnik (segment "Critic's Corner,' 'Roast Your Loved One") |
| Belinda Balaski | Bernice Pitnik (segment "Critic's Corner' 'Roast Your Loved One") |
| Justin Benham | Pitnik Boy (segment "Critic's Corner,' 'Roast Your Loved One") |
| Erica Gayle | Pitnik Girl (segment "Critic's Corner,' 'Roast Your Loved One") |
| T.K. Carter | Host (segment "Silly Pate") |
| Phil Proctor | Mike (segment "Silly Pate") |
| Ira Newborn | Fred (segment "Silly Pate") |
| Bryan Cranston | Paramedic #1 (segment "Roast Your Loved One") |
| Karen Montgomery | Karen (segment "Silly Pate") |
| Robert Picardo | Rick Raddnitz (segment "Roast Your Loved One") |
| Rip Taylor | Himself (segment "Roast Your Loved One") |
| Slappy White | Himself (segment "Roast Your Loved One") |
| Jackie Vernon | Himself (segment "Roast Your Loved One") |
| Henny Youngman | Himself (segment "Roast Your Loved One") |
| Charlie Callas | Himself (segment "Roast Your Loved One") |
| Steve Allen | Himself (segment "Roast Your Loved One") |
| William Marshall | Pirate Captain (segment "Video Pirates") |
| Tino Insana | Mr. Sylvio (segment "Video Pirates") |
| Donald Gibb | Graceless Pirate (segment "Video Pirates") |
| Mark Bringelson | Theatre Customer #1 (segment "Antony & Cleopatra ") |
| Frank Collison | Grizzled Pirate (segment "Video Pirates") |
| Victoria Ann Lewis | Theatre Customer #2 (segment "Antony & Cleopatra ") |
| Bill Taylor | Gruesome Pirate (segment "Video Pirates") |
| Ed Begley Jr. | Griffin (segment "Son of the Invisible Man") |
| Vivian Bonnell | Theatre Customer #3 |
| Jenny Agutter | Cleopatra (segment "Antony & Cleopatra Promo") |
| Chuck Lafont | Trent (segment "Son of the Invisible Man") |
| Raye Birk | Vanya |
| Pamla Vale | Woman in Pub (segment "Son of the Invisible Man") |
| Larry Hankin | Man in Pub (segment "Son of the Invisible Man") |
| Kellye Nakahara | Theatre Customer #4 |
| Philip Bruns | French Ventriloquist Dummy - Manager |
| Garry Goodrow | Checker Player (segment "Son of the Invisible Man") |
| Roger La Page | London Bobby (segment "Son of the Invisible Man") |
| Dick Miller | Danny Clayton |
| John Ingle | Felix Van Dam (segment "Art Sale") |
| Robina Suwol | Woman |
| Angel Tompkins | First Lady (segment "First Lady of the Evening") |
| Terence McGovern | Salesman (segment "First Lady of the Evening") |
| Michael Hanks | Announcer (segment "First Lady of the Evening") |
| Matt Adler | George (segment "Titan Man") |
| Kelly Preston | Violet (segment "Titan Man") |
| Ralph Bellamy | Mr. Gower (segment "Titan Man") |
| Howard Hesseman | Rupert King (segment "Titan Man") |
| Steve Cropper | Customer (segment "Titan Man") |
| Christopher Wolf | Mascot 'Bip' (segment "Titan Man") |
| Marc McClure | Ray (segment "Video Date") |
| Russ Meyer | Video Salesman (segment "Video Date") |
| Corinne Wahl | Sherrie (segment "Video Date") |
| Andrew Dice Clay | Frankie (segment "Video Date") |
| Willard E. Pugh | Speaking Cop (segment "Video Date") |
| Carrie Fisher | Mary Brown (segment "Reckless Youth") |
| Paul Bartel | Doctor (segment "Reckless Youth") |
| Herb Vigran | Agent (segment "Reckless Youth") |
| Tracy Hutchinson | Floozie (segment "Reckless Youth") |
| Mike Mazurki | Dutch (segment "Reckless Youth") |
| Frank Beddor | Ken (segment "Reckless Youth") |
| Michael Young | Lifescenes Magazine - Jim Scott |
| Roger Barkley | Herbert (segment "Critic's Corner") |
| Martin Goslins | French Ventriloquist (segment "French Ventriloquist") |
| Al Lohman | Frankel (segment "Critic's Corner") |
| Bela Lugosi | Pete Jones |
| Bernie Casey | Maj. Gen. Hadley (segment "The Unknown Soldier") |
| Ronny Cox | Gen. Balentine (segment "The Unknown Soldier") |
| David E. Harshbarger | The Claw (closing credits) |
| Helen Kelly | Nurse (segment "Hospital") |
| Marie Lamarre | Model |
| Wallace Langham | Private Anson W. Pucket (segment "The Unknown Soldier") |
| Huey Lewis | Himself in music video (segment "Murray in Videoland") |
| Robert Loggia | Gen. McCormick (segment "The Unknown Soldier") |
| Kevin Marcy | Secret Service Agent (segment "Murray in Videoland") |
| Paul McMichael | Daughter at sperm bank (Lifescenes Magazine Celebrity Sperm Bank) |
| Lyle Talbot | Prescott Townsend (segment "Amazon Women on the Moon") |
| USC Trojan Marching Band | Marching Band (segment "Titan Man") |
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